APP ELISA Kit for Pig(Sus scrofa) | EIAab.comAPP ELISA Kit for Pig(Sus scrofa)

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APP (Gene name),

Amyloid beta A4 protein (Protein name ), A4_PIG from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

APP;

Protein name:

Amyloid beta A4 protein;

Alternative:

Alzheimer disease amyloid A4 protein homolog;ABPP(APP);

Organism:

Pig (Sus scrofa).

General Annotation

Sub Unit:

Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, and SHC1, NUMB and DAB1 (By similarity). Binding to Dab1 inhibits its serine phosphorylation (By similarity). Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains) (By similarity), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts with CPEB1, ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; this is promoted by heparin binding.

Function:

N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Subcellular Location:

Membrane Single-pass type I membrane protein Membrane clathrin-coated pit Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons.

Protein Attributes:

Sequence length:

770

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

770:

KMQQNGYENP | TYKFFEQMQN |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Ssc.14258

String:

P79307

Pfam:

PF10515

SMR:

P79307

KEGG:

ssc:397663

Uniprot:

P79307

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ELISA Kit for Pig Amyloid beta A4 protein

Cat.:

E0946h

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Packing:

96T

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ELISA Kit for Pig Amyloid beta A4 protein

Cat.:

E0946m

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96T

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ELISA Kit for Pig Amyloid beta A4 protein

Cat.:

E0946r

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96T

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ELISA Kit for Pig Amyloid beta A4 protein

MSDS:

Please sign in first.

ELISA Kit for Pig Amyloid beta A4 protein

MSDS:

Please sign in first.

ELISA Kit for Pig Amyloid beta A4 protein

MSDS:

Please sign in first.

ELISA Kit for Pig Amyloid beta A4 protein

Cat.:

E0946p

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MSDS:

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Packing:

96T

CLIA Kit for Pig Amyloid beta A4 protein

Cat.:

U0946m

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MSDS:

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Packing:

96T

CLIA Kit for Pig Amyloid beta A4 protein

Cat.:

U0946p

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MSDS:

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Packing:

96T

CLIA Kit for Pig Amyloid beta A4 protein

MSDS:

Please sign in first.

CLIA Kit for Pig Amyloid beta A4 protein

MSDS:

Please sign in first.

CLIA Kit for Pig Amyloid beta A4 protein

MSDS:

Please sign in first.

CLIA Kit for Pig Amyloid beta A4 protein

Cat.:

U0946r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Pig Amyloid beta A4 protein

Cat.:

U0946h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Pig Amyloid beta A4 protein

Cat.:

P0946Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Pig Amyloid beta A4 protein

Cat.:

P0946Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Pig Amyloid beta A4 protein

Cat.:

P0946Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Pig Amyloid beta A4 protein

Monoclonal Antibody for Pig Amyloid beta A4 protein

Protein for Pig Amyloid beta A4 protein

Cat.:

R0946h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Pig Amyloid beta A4 protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Amyloid precursor protein 770."
Kimura A. , Takahashi T.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Evaluation and characterization of a porcine small intestine cDNA library."
Winteroe A.K. , Fredholm M.
Submitted (1997-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-136
tissue: Small intestine.
3.

"Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis."
Johnstone E.M. , Chaney M.O. , Norris F.H. , Pascual R. , Little S.P.
Brain Res. Mol. Brain Res.10:299-305(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 667-723
tissue: Brain.

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